The P Brief

Small-molecule NNMT inhibitor that boosts cellular energy expenditure and fat metabolism. Raises NAD+ in adipose tissue and supports fat-cell shrinkage. Subcutaneous injection only — no oral form in this protocol.

50-100 mgOnce daily

AICAR

An AMPK activator that mimics the metabolic effects of exercise. Increases fatty acid oxidation, glucose uptake, and mitochondrial biogenesis. Known as an 'exercise in a pill' compound. Also studied for cardiac protection during ischemia.

25-50 mgOnce daily

AOD-9604

250-500 mcgOnce daily (optionally twice)

Modified fragment of human growth hormone that drives lipolysis without affecting blood sugar or IGF-1. Favored for fat-loss and recomposition cycles where the user wants nothing else moving.

Adipotide

A peptidomimetic that targets and destroys blood vessels feeding white adipose (fat) tissue, causing fat cell apoptosis. Originally studied as an anti-obesity agent in primates. Causes rapid fat loss by cutting off blood supply to fat cells.

100-500 mcgOnce daily

Ara-290 (Cibinetide)

An innate repair receptor agonist derived from erythropoietin. Does not stimulate red blood cell production but activates tissue repair pathways. Being studied for small fiber neuropathy, sarcoidosis, and diabetic complications.

4 mgOnce daily

BPC-157

250-500 mcg1-2x daily depending on severity

Body Protection Compound-157, a synthetic peptide derived from a protein in gastric juice. Regenerative effects across gut, muscles, tendons, ligaments, and the nervous system. Staple of healing and recovery protocols.

CJC-1295 (no DAC)

100-200 mcg1-3x daily (AM, PM, pre/post workout)

Short-half-life GHRH analog used for pulsed GH release. Typically stacked with Ipamorelin to mimic natural pulsatile secretion. Drives fat loss, lean muscle, recovery, and sleep quality.

CJC-1295 (with DAC)

Long-acting GHRH analog with a Drug Affinity Complex extending half-life to ~8 days. Sustained GH and IGF-1 elevation drives muscle, fat loss, recovery, and skin/anti-aging benefits.

1-2 mg1-2x per week

Cagrilintide

Long-acting amylin analog. Hits brain appetite-regulation centers to drive satiety and slow gastric emptying. Stacks well with GLP-1 agonists (semaglutide / tirzepatide) for compounded fat-loss results.

0.1-0.6 mgOnce weekly

DSIP (Delta Sleep-Inducing Peptide)

Sleep & Recovery

A neuropeptide that promotes delta wave (deep) sleep. Discovered in 1977 from cerebral venous blood of sleeping rabbits. Normalizes sleep architecture, reduces stress-related insomnia, and may regulate cortisol and LH release.

100-300 mcgOnce daily

Dermorphin

10-20 mgOnce daily (oral or sublingual)

A heptapeptide originally found in the skin of South American frogs. Extremely potent mu-opioid receptor agonist — 30-40x more potent than morphine. Used in research for pain management. Not for casual use due to potency.

50-200 mcgAs needed

Dihexa

Cognitive Enhancement

An angiotensin IV analog that is millions of times more potent than BDNF at promoting neural connections. Studied for Alzheimer's and cognitive decline. Extremely potent — effective at very low doses.

Epithalon

10 mgDaily, split AM 5 mg + PM 5 mg

Synthetic tetrapeptide mimicking the pineal-gland peptide epithalamin. Studied for telomerase activation, DNA repair support, immune enhancement, and sleep/circadian regulation. A staple of anti-aging and longevity protocols.

FOXO4-DRI

A cell-penetrating peptide that selectively induces apoptosis (programmed cell death) in senescent cells. A true senolytic agent — clears zombie cells that accumulate with age and drive inflammation, tissue dysfunction, and aging.

5-10 mgEvery 3 days

GHK-Cu

5-10 mgDaily microdoses or 2-3 larger injections weekly

Naturally occurring copper peptide. Drives tissue regeneration, collagen and hair growth, and reduces inflammation. Used widely in anti-aging and cosmetic protocols; systemic benefits when administered subcutaneously.

GHRP-2

100-300 mcg2-3 times daily

Growth Hormone Releasing Peptide-2. More potent GH release than GHRP-6 with less appetite stimulation. Good balance of efficacy and side effects. Increases GH, IGF-1, and also has slight cortisol and prolactin elevation.

GHRP-6

100-300 mcg2-3 times daily

Growth Hormone Releasing Peptide-6. Potent GH secretagogue that also strongly stimulates appetite via ghrelin activation. Useful for those wanting to increase both GH levels and caloric intake for mass building.

GLOW (BPC-157 + GHK-Cu + TB-500)

Synergistic peptide blend: 10 mg BPC-157, 10 mg TB-500, 50 mg GHK-Cu per vial. Deep tissue repair, inflammation reduction, collagen and skin regeneration. One injection covers what would otherwise be three.

1.6 mgDaily

Glutathione

200-600 mg2-3 times per week

The body's master antioxidant — a tripeptide (glutamate, cysteine, glycine) produced in every cell. Neutralizes free radicals, supports detoxification, brightens skin, and supports immune function. Levels decline with age and illness.

HCG (Human Chorionic Gonadotropin)

500-1000 IU2-3x per week (e.g., Mon/Wed/Fri)

Mimics luteinizing hormone (LH); stimulates the testes to produce testosterone and sperm. Used in TRT support, fertility, and post-cycle therapy to preserve testicular function and prevent atrophy.

HGH Fragment 176-191

The fat-burning fragment of human growth hormone (amino acids 176-191). Stimulates lipolysis and inhibits lipogenesis without the growth-promoting or diabetogenic effects of full HGH. Similar to AOD-9604 but slightly different structure.

250-500 mcgTwice daily

HMG (Human Menopausal Gonadotropin)

A purified preparation containing FSH and LH activity. Used in fertility treatments for both men and women. In men, stimulates both testosterone production (via LH) and spermatogenesis (via FSH). More complete gonadotropin support than HCG alone.

75-150 IUEvery other day

Hexarelin

100-200 mcg2-3 times daily

One of the strongest GHRP peptides for growth hormone release. Also has cardioprotective properties and can strengthen cardiac tissue. More potent GH release than Ipamorelin but with more side effects (cortisol, prolactin elevation).

IGF-1 LR3

Long-acting analog of Insulin-like Growth Factor 1. The LR3 modification extends its half-life to ~20 hours. Promotes muscle growth, recovery, and hyperplasia (new muscle cell formation). Significantly more potent than natural IGF-1.

20-50 mcgOnce daily

Ipamorelin

100-300 mcg1-3x daily (AM, post-workout, PM)

Selective GH secretagogue that triggers GH release without bumping cortisol or prolactin. One of the cleanest tolerated GH-releasing peptides; commonly stacked with CJC-1295 (no DAC) for pulsatile secretion.

KLOW (BPC-157 + TB-500 + GHK-Cu + KPV)

Advanced healing and anti-inflammatory blend: 10 mg BPC-157, 10 mg TB-500, 50 mg GHK-Cu, and 10 mg KPV per vial. KPV adds gut-protective and immune-modulatory action on top of the GLOW base.

1.6 mgDaily

KPV

A tripeptide derived from alpha-MSH (alpha-melanocyte-stimulating hormone). Potent anti-inflammatory that inhibits NF-kB signaling. Effective for gut inflammation, skin conditions, and systemic inflammation without immunosuppression.

200-500 mcgOnce daily

Kisspeptin-10

100-200 mcgDaily or 3-5x/week (e.g., Mon-Fri)

Synthetic version of a peptide that initiates GnRH release. Central regulator of the reproductive hormone cascade — boosts LH, testosterone, and supports fertility in both men and women.

LL-37

100-500 mcg1x daily (every other day if sensitive)

Naturally occurring antimicrobial peptide from the innate immune system (cathelicidin family). Antibacterial, antifungal, antiviral activity; modulates inflammation and accelerates wound healing. Used for chronic infections (sinus, gut, Lyme, mold), biofilms, and autoimmune/inflammatory conditions.

MK-677 (Ibutamoren)

10-25 mgOnce daily (oral)

An oral growth hormone secretagogue that mimics ghrelin. Not technically a peptide but a non-peptide agonist of the ghrelin receptor. Taken orally, making it convenient. Significantly increases GH and IGF-1 levels.

MOTS-c

5-15 mgTotal weekly dose, split across 3x weekly injections

Mitochondrial-derived peptide regulating metabolic function. Improves insulin sensitivity, drives fat loss, boosts physical performance, and supports longevity via AMPK activation.

Melanotan 1 (Afamelanotide)

Tanning & Melanocortin

A linear alpha-MSH analog that stimulates melanogenesis (melanin production) in the skin. FDA-approved as Scenesse for erythropoietic protoporphyria. Provides UV-free tanning and photoprotection. Safer profile than MT-2 with fewer side effects.

0.5-1 mgOnce daily

Melanotan 2

Tanning & Melanocortin

A cyclic melanocortin peptide analog that stimulates melanin production for skin tanning. Also has effects on sexual arousal and appetite suppression. More potent than MT-1 but with more side effects including nausea and mole darkening.

0.25-0.5 mgOnce daily during loading, then 1-2x/week

NAD+ (Nicotinamide Adenine Dinucleotide)

50-250 mg2-3x per week, daily in intensive protocols

Vital coenzyme in cellular energy metabolism, DNA repair, and healthy aging. Injectable supplementation enhances mitochondrial function, mental clarity, fatigue recovery, and longevity. Common in anti-aging, detox, and performance protocols.

Oxytocin

10-24 IU1-2 times daily (nasal spray)

The 'love hormone' — a neuropeptide produced in the hypothalamus. Promotes social bonding, trust, empathy, and reduces anxiety. Used medically to induce labor and treat postpartum bleeding. Also studied for autism and social anxiety disorders.

PT-141 (Bremelanotide)

Sexual Health

Melanocortin receptor agonist FDA-approved for hypoactive sexual desire disorder (Vyleesi). Works centrally in the brain to increase sexual desire and arousal. Effective in both men and women.

0.5-1.0 mgAs needed (max 8 doses/month, max 1/24 hours)

Retatrutide

0.25-1.0 mg3x weekly, titrate up as tolerated

Triple agonist (GLP-1 + GIP + glucagon). Investigational compound under clinical trial; aggressive weight-loss and metabolic improvement signal beyond semaglutide or tirzepatide. Provided here as laboratory/research reference only — not yet FDA-approved.

SLU-PP-332

250-500 mcg3x weekly (M/W/F), or daily for aggressive cycles

Novel purinergic-receptor agonist investigated for metabolism, fat oxidation, endurance capacity, and mitochondrial function. May produce endurance-like effects without cardiovascular stimulation.

SNAP-8

100-500 mcgOnce daily (topical or injection)

An octapeptide that mimics the N-terminal end of SNAP-25, competing with natural SNAP-25 for positions in the SNARE complex. Reduces neuromuscular activity, smoothing wrinkles similarly to botulinum toxin but non-toxic. Primarily used topically.

SS-31 (Elamipretide)

A mitochondria-targeted tetrapeptide that penetrates cell membranes and concentrates in mitochondria. Stabilizes cardiolipin, restores electron transport chain function, and reduces oxidative stress. Being developed for mitochondrial diseases and heart failure.

1-2 mgOnce daily

Selank

Cognitive Enhancement

Synthetic peptide derived from tuftsin. Anxiolytic, antidepressant, and cognitive-enhancing effects. Reduces anxiety, sharpens mental clarity, modulates the immune system. Administered intranasally for fast CNS absorption.

250-500 mcg1-2x daily

Semaglutide

GLP-1 receptor agonist. Increases insulin secretion, blunts appetite, slows gastric emptying. Originally developed for type 2 diabetes; now the dominant peptide in the fat-loss landscape. Provided here as research/laboratory reference.

0.25-1.0 mgOnce weekly

Semax

Cognitive Enhancement

Synthetic peptide derived from ACTH. Nootropic with neuroprotective, cognitive-enhancing, and mood-regulating effects. Boosts BDNF expression; sharpens memory, focus, and stress resilience. Administered intranasally.

300-1000 mcg1-2x daily

Sermorelin

A GHRH analog (GRF 1-29) that stimulates the pituitary to produce and release growth hormone naturally. FDA-approved for GH deficiency diagnosis. Preserves natural GH pulsatility and feedback mechanisms.

200-300 mcgOnce daily

Survodutide

Dual GLP-1/glucagon receptor agonist developed by Boehringer Ingelheim. Targets both appetite reduction and increased energy expenditure. Shows promise for both weight loss and NASH/fatty liver disease treatment.

0.5-6 mgOnce weekly

TB-500

1 mg3x weekly (e.g., Mon/Wed/Fri)

Synthetic Thymosin Beta-4. Drives cell migration, soft-tissue regeneration, and inflammation reduction. Goes after tendons, ligaments, and muscle injury.

TB4-FRAG

A fragment of Thymosin Beta-4 (amino acids 17-23), also known as Ac-SDKP. Provides targeted anti-inflammatory and anti-fibrotic properties with fewer systemic effects than full TB-500.

200-750 mcgOnce daily

Tesamorelin

1 mgOnce daily, 5 days per week (e.g., Mon-Fri)

GHRH analog that stimulates natural HGH production. FDA-approved for visceral adipose reduction. Improves body composition, reduces fat mass, supports lean muscle, and offers cognitive and anti-aging benefits.

Thymalin

A thymic peptide bioregulator containing a complex of polypeptides from the thymus gland. Developed in Russia for immune restoration. Normalizes T-cell ratios, enhances immune surveillance, and has anti-aging properties related to immune function.

10 mgOnce daily

Thymosin Alpha-1

A thymic peptide that modulates the immune system by enhancing T-cell function and dendritic cell activity. FDA-approved in over 35 countries (as Zadaxin) for hepatitis B and C. Powerful immune modulator without overstimulation.

1.6 mgTwice per week

Tirzepatide

1.25-5.0 mgTwice weekly (e.g., Mon/Thu or Tue/Fri)

Dual GIP and GLP-1 receptor agonist. Amplifies insulin response, blunts appetite, drives fat loss with stronger glycemic control than semaglutide alone. Provided for research/laboratory reference.

VIP (Vasoactive Intestinal Peptide)